Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis.

ABSTRACT: Circulating blood proteins and enzymes are maintained within normal physiological and clinically relevant concentration ranges. Excursions from normality include diagnostic markers and causes of disease. Rapid and persistent changes in the levels and functions of circulating blood components can reflect the functions of multiple endocytic lectin receptors. The majority of non-albumin blood proteins are post-translationally modified with sialylated N-glycans bearing cryptic ligands of various endocytic lectin receptors. During time in circulation, these cryptic ligands are progressively unmasked thereby contributing to glycoprotein half-life and abundance. The relationships between distinct lectin receptors and their endogenous ligand repertoires are not easily established. Herein we apply

SUBMITTER: Restagno D 

PROVIDER: S-EPMC12234678 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature