Integrated bioinformatics analysis identifies CHAD association with osteoporosis and in vitro chondrogenic effects of Wogonin.

ABSTRACT: Osteoporosis (OP), characterized by reduced bone density and increased fracture risk. Current therapies have limitations due to side effects and variable efficacy, necessitating exploration of novel therapeutic targets and alternatives like Traditional Chinese Medicine (TCM). The molecular mechanisms driving OP remain incompletely understood. This study utilized integrated bioinformatics approaches to identify potentially dysregulated genes in OP and explored in vitro effects of TCM compounds targeting top identified genes. Differentially expressed genes (DEGs) associated with OP were identified by integrating bulk and single-cell RNA sequencing datasets. Potential therapeutic compounds targeting selected DEGs were screened from a TCM database using molecular docking to predict binding aff

SUBMITTER: Lan KF 

PROVIDER: S-EPMC12234696 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature