The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis.

ABSTRACT: Linkage disequilibrium (LD) provides information about positional cloning, linkage, and evolution that cannot be inferred from other evidence, even when a correct sequence and a linkage map based on more than a handful of families become available. We present theory to construct an LD map for which distances are additive and population-specific maps are expected to be approximately proportional. For this purpose, there is only a modest difference in relative efficiency of haplotypes and diplotypes: resolving the latter into 2-locus haplotypes has significant cost or error and increases information by about 50%. LD maps for a cold spot in 19p13.3 and a more typical region in 3q21 are optimized by interval estimates. For a random sample and trustworthy map the value of LD at large distance c

SUBMITTER: Maniatis N 

PROVIDER: S-EPMC122347 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature