Genome-scale metabolic model-guided systematic framework for designing customized live biotherapeutic products.

ABSTRACT: For the successful development of live biotherapeutic products (LBPs), which are promising microbiome-based therapeutics, it is required to rigorously evaluate their quality, safety, and efficacy. To this end, we present a model-guided framework where genome-scale metabolic models (GEMs) can be exploited for characterizing LBP candidate strains and their metabolic interactions with adjacent microbiome and host cells at a systems level. In this perspective, we outline a GEM-based strategy for screening, assessment, and design of personalized multi-strain LBPs.

SUBMITTER: Lee YQ 

PROVIDER: S-EPMC12234829 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature