Machine learning identifies KRT8 dysregulation and endothelial remodeling in Moyamoya disease.

ABSTRACT: Moyamoya disease (MMD) is a rare occlusive cerebrovascular disease, and its pathological mechanism remains unclear at present. The abnormal vascular remodeling may be involved in vascular endothelial cells. In this study, RNA seq was performed on the superficial temporal arteries of 10 patients with MMD. Integrated analysis was conducted by combining validation set with training set. Key genes were identified through differential analysis and WGCNA. The functions of potential biomarkers were explored by methods such as correlation analysis, KEGG analysis, PPI network, and tube formation experiments. Integrated analysis of three cohorts (43 MMD vs. 26 controls) identified 19 shared DEGs, including upregulated KRT8/KRT18 and downregulated NT5C2 (P < 0.001). Enrichment revealed dysregulation

SUBMITTER: Han Z 

PROVIDER: S-EPMC12234845 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature