Unlocking potent anti-tuberculosis natural products through structure-activity relationship analysis.

ABSTRACT: Tuberculosis (TB) remains a world health problem due to the high number of affected individuals, high mortality rates, prolonged treatment durations, and the increasing prevalence of resistance to commercial TB drugs. The emergence of resistance to anti-TB drugs has necessitated urgent research into drug discovery and development, focusing on novel mechanisms of action against Mycobacterium tuberculosis resistant strains. Natural products, with their remarkable structural diversity and bioactivity, are promising sources for the development of new TB drugs or the identification of potential chemical scaffolds exhibiting potent and novel biological activity with minimal or no cytotoxicity to host cells. This review focuses on potent anti-TB natural products with minimum inhibitory concentrat

SUBMITTER: Abdjul DB 

PROVIDER: S-EPMC12234934 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature