The Bidirectional Relationship Between Sleep and Pain in Crohn's Disease: A Daily Diary Study.

ABSTRACT:

Background

Pain is common in Crohn's disease (CD) even after endoscopic healing is achieved. Depression, sleep disturbances, fatigue, and worry about pain impact the pain experience. There is a bidirectional relationship between sleep and pain, though it has received minimal attention in CD. Herein, we sought to comprehensively assess this relationship in CD using daily diaries.

Method

Patients with active symptoms of insomnia and CD were recruited as part of an ongoing clinical trial. Participants completed 14-day diaries on sleep patterns and CD symptoms. Temporal associations between sleep and pain were assessed using cross-lagged path analysis and controlled for age, sex, and menstrual cycle.

Results

Overall, 26 participants completed 14-day diaries. All assessed

SUBMITTER: Salwen-Deremer JK 

PROVIDER: S-EPMC12235134 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature