Wild <i>Cordyceps sinensis</i> exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic.

ABSTRACT:

Introduction

Wild Cordyceps sinensis (C. sinensis) is a Chinese medicinal material known for its renal and pulmonary benefits. However, inorganic arsenic in wild Cordyceps sinensis may accumulate in the body following prolonged consumption; therefore, rigorous safety evaluations are needed.

Methods

This study compared the impacts of wild Cordyceps sinensis at the maximum clinical dose and equivalent doses of inorganic arsenic (16.36 mg/kg) to its total arsenic dose on organ indices, arsenic accumulation, and functional and pathological changes in the liver and kidney in mice, aiming to explore the safety of consuming wild Cordyceps sinensis. Arsenic accumulation in organs was measured via ICP-MS, while serum markers of liver and kidney functions were assessed via ELIS

SUBMITTER: Gao L 

PROVIDER: S-EPMC12235186 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature