Array-based polymer-phage biosensors for detection and differentiation of bacteria.

ABSTRACT: Pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), pose significant challenges to public health due to their resistance to conventional antibiotics. Early and accurate identification of bacterial species and discrimination of their strains is critical for guiding effective treatments and infection control. In this study, we develop a polymer-phage sensor platform that integrates polymer-based fluorescence sensing with phage-host specificity for bacterial identification. The sensor successfully differentiates three bacterial species (S. aureus, E. coli, and B. subtilis) and closely related strains of S. aureus (methicillin-sensitive Staphylococcus aureus (MSSA) and MRSA) with high classification accuracy (94-100%) and c

SUBMITTER: Ochirbat E 

PROVIDER: S-EPMC12235245 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature