Hippocampal Subfields Volume: Another Hint of the Continuum Between CAA and AD?

ABSTRACT:

Objective

This study investigates whether cerebral amyloid angiopathy (CAA) patients with Alzheimer's disease (AD)-like CSF profile exhibit radiological features characteristic of AD, specifically reduced hippocampal and amygdala volumes.

Methods

From a database of 162 probable CAA cases (Boston 2.0 criteria) at the Fondazione IRCCS Istituto Neurologico Carlo Besta, 44 patients underwent CSF analysis (Aβ42, Aβ40, and p-Tau181) and brain MRI with volumetric T1 sequences. Participants with CSF levels of Aβ42 < 640 pg/mL and p-Tau181 > 56.5 pg/mL were classified as CAA/AD+; otherwise, as CAA/AD-. Hippocampal and amygdala volumes were assessed using volBrain software, and statistical analyses included t-tests and Mann-Whitney U tests.

Results

CAA/AD+ patients (n = 22) wer

SUBMITTER: Storti B 

PROVIDER: S-EPMC12235323 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature