Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non-Appalachian patients.

ABSTRACT: Emerging evidence reports that regulation of the extracellular matrix influences the progression of colorectal cancer (CRC). The present study investigated regulation of the extracellular matrix proteome in colorectal malignancy within a high-risk Appalachian population compared with non-Appalachian populations. A targeted mass spectrometry imaging proteomic method directed at collagen regulation was used. Tissue microarrays (TMAs) comprising of matched CRC with adjacent normal to tumor (NAT) from 45 patients were constructed into 86 samples to evaluate the extracellular matrix proteome (ECM). A total of five specific peaks were discovered to differ between NAT and tumor with high sensitivity and specificity by receiver operating characteristic (AUROC) ≥0.7, Wilson/Brown P<0.0002. Evaluati

SUBMITTER: Sougiannis AT 

PROVIDER: S-EPMC12235701 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature