Metabolic Effects of Cellular Necrosis Caused by Exfoliative Toxin C (ExhC) from <i>Mammaliicoccus sciuri</i>.

ABSTRACT: Exfoliative toxins (ETs) are glutamyl endopeptidases (GEPs) belonging to the chymotrypsin-like serine protease family (CLSPs), and they play crucial roles in diverse skin diseases. Specifically, exfoliative toxin C (ExhC), expressed by Mammaliicoccus sciuri, is an atypical CLSP and has been classified as a moonlighting protein due to its ability to induce necrosis in specific cell lines, inhibit the phagocytic activity of macrophages, and cause skin exfoliation in pigs and mice. The latter function is attributed to the high specificity of ExhC for porcine and murine desmoglein-1, a cadherin that contributes to cell-cell adhesion within the epidermis. Although the amino acid residues responsible for ExhC-induced necrosis have been identified, the specific cellular metabolic pathways

SUBMITTER: Gismene C 

PROVIDER: S-EPMC12235709 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature