Ferritin-based nanoparticle vaccine protects neonatal piglets against porcine epidemic diarrhea virus challenge following immunization of pregnant sows.

ABSTRACT: Porcine epidemic diarrhea virus (PEDV) is an enteropathogenic coronavirus that causes severe diarrhea and high mortality in neonatal piglets, resulting in significant economic losses to the pig industry worldwide. Given that current commercial vaccines lack adequate protection against variant PEDV strains, there is an urgent need for the development of more effective vaccines to control PEDV infection. Here, a novel nanoparticle vaccine displaying the core neutralizing epitope CO-26 K-equivalent (COE) of PEDV spike protein was developed using Helicobacter pylori ferritin as an antigen delivery system, and its protective efficacy against the highly virulent PEDV LYL strain in suckling piglets was evaluated following immunization of pregnant sows. Compared to the COE monomer vaccines, COE-fe

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12235928 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature