High-Level Primary Pretomanid-Resistant with <i>ddn</i> In-Frame Deletion of and Its Association with Lineage 4.5 in China.

ABSTRACT: Pretomanid (PMD) is a key antibiotic of the newest multidrug-resistant or rifampicin-resistant tuberculosis treatment regimen "BPaL", but knowledge of its resistance mutations is still limited, especially in China, as it was approved only in late 2024. We analyzed a collection of (MTB) isolates from China including the whole-genome sequencing and drug susceptibility testing data and extended analysis to other 2165 isolates from lineage 4. We found in-frame deletion variants in the ddn genome sequence in the isolates collected in Xinjiang Uyghur Autonomous Region, China, with a high level of PMD resistance without pre-exposure to PMD belonging to sublineage 4.5. The extended analysis found that in-frame deletion variants occurred more frequently in sublineage 4.5. Some isolates conta

SUBMITTER: Pei S 

PROVIDER: S-EPMC12235975 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature