Identification of Small Open Reading Frame-encoded Proteins in the Human Genome.

ABSTRACT: One of the main goals of the Human Genome Project is to identify all protein-coding genes. There are ∼ 20,500 protein-coding genes annotated in the human reference databases. However, in the last few years, proteogenomics studies have predicted thousands of novel protein-coding regions, including low-molecular-weight proteins encoded by small open reading frames (sORFs) in untranslated regions of messenger RNAs and non-coding RNAs. Most of these predictions are based on bioinformatics analyses and ribosome footprint data. The validity of some of these sORF-encoded proteins (SEPs) has been established through functional characterization. With the growing number of predicted novel proteins, a strategy to identify reliable candidates that warrant further studies is needed. In this study, we d

SUBMITTER: Kore H 

PROVIDER: S-EPMC12236067 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature