Precision dendritic-supramolecular glycan assemblies for probing multivalent lectin interactions.

ABSTRACT: Multivalent glycan-protein binding events participate in various physiological functions including cell signaling, immune response, and pathogen-host recognition, among others. The complexity of these processes has driven sustained interest in developing densely functionalized glycan nanoassemblies to probe and modulate these important interactions. While synthetic glyconanomaterials have demonstrated significant promise in nanomedicine and biotechnology applications, achieving precise control over their architecture remains challenging. To address this limitation, we present a new method of synthesizing molecular glycan nanoassemblies by integrating the dense functionalization of dendritic architectures with the preorganized scaffolding of metallosupramolecular frameworks. A family of Fe(

SUBMITTER: Bhide TM 

PROVIDER: S-EPMC12236194 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature