Delineating the Transmission of Subthreshold Psychosis Symptoms Across Generations: The Philadelphia Family Neurodevelopmental Cohort.

ABSTRACT:

Background and hypothesis

Intergenerational factors are implicated in development of schizophrenia spectrum disorders. Studying psychosis spectrum (PS) symptoms dimensionally in a longitudinal, prospective intergenerational cohort can provide crucial insight into risk pathways. Thus, we established the Philadelphia Family Neurodevelopmental Cohort (PFNC), an intergenerational study that follows Philadelphia Neurodevelopmental Cohort (PNC) participants as they transition to parenthood, along with their offspring. This first report describes the creation of the PFNC, followed by an examination of longitudinal associations between risk factors assessed in adolescence (PS symptoms, cognition, and traumatic life events) and mental health and resilience outcomes in parenthood.

Study d

SUBMITTER: White LK 

PROVIDER: S-EPMC12236350 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature