Consensus recommendations for hyperpolarized [1-¹³C]pyruvate MRI multi-center human studies.

ABSTRACT: MRI of hyperpolarized (HP) [1-¹³C]pyruvate allows in vivo assessment of metabolism and has translated into human studies across diseases at 15 centers worldwide. To determine consensus on best practice for multi-center studies for development of clinical applications. This paper presents the results of a two-round formal consensus building exercise carried out by experts with HP [1-¹³C]pyruvate human study experience. Twenty-nine participants from 13 sites brought together expertise in pharmacy methods, MR physics, translational imaging, and data analysis with the goal of providing recommendations and best practice statements on conduct of multi-center human studies of HP [1-¹³C]pyruvate MRI. Overall, the group reached consensus on approximately two-thirds

SUBMITTER: Punwani S 

PROVIDER: S-EPMC12236423 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature