A causal role for the posterior corpus callosum in bimanual coordination.

ABSTRACT: Inter-areal communication is crucial for brain function. Given the largely contralateral organization of the brain, bimanual coordination likely involves interactions across the two cerebral hemispheres for motor planning and execution. The parietal reach region (PRR) is an early node in the sensorimotor transformation stream. Here we examine the contributions of direct callosal connections between left and right PRR to bimanual coordination. Using manganese-enhanced magnetic resonance imaging, we traced callosal pathways crossing the midline and found that PRR-PRR connections are restricted to the splenium. We then temporarily blocked these fibers with lidocaine while measuring behavioral performance and interhemispheric coherence. Blockade reduced task-specific PRR-PRR coherence during b

SUBMITTER: Kang JU 

PROVIDER: S-EPMC12236483 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature