Antimicrobial Loaded Graft-Copolymer Nanoparticles for Treatment of <i>Pseudomonas aeruginosa</i> Infections.

ABSTRACT: Nearly 80% of cystic fibrosis patients are affected by persistent lung infections, with Pseudomonas aeruginosa being one of the major culprits. Treatment of P. aeruginosa is further complicated by its ability to form biofilms. Anionic compounds within the biofilm and thick cystic fibrosis mucus interact with cationic antimicrobials, hindering treatment efficacy. In this study, we investigated the treatment of lung infections by delivering antimicrobials via polyelectrolyte surfactants that are composed of an anionic poly(alkylacrylic acid) backbone with grafted polyetheramine pendent chains. When combined with cationic antimicrobials, they selfassemble into nanoparticles via electrostatic interactions. We assessed the role of backbone chemistry and graft density on nanopartic

SUBMITTER: Soler YV 

PROVIDER: S-EPMC12236493 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature