Transformer-based Deep Learning for Glycan Structure Inference from Tandem Mass Spectrometry.

ABSTRACT: Glycans play critical roles in diverse biological processes, but their structural analysis by tandem mass spectrometry (MS/MS) remains a major challenge due to their branched structure and stereochemistry. Traditional computational methods, such as database searching, are constrained by the scope of existing libraries and can be computationally intensive. While recent deep learning models have advanced the field, they often struggle to capture the complex, long-range dependencies within MS/MS spectra required for accurate inference. To address these challenges, we present GlycoBERT and GlycoBART, novel transformer-based models for glycan structure prediction from MS/MS data. GlycoBERT, a sequence classifier, achieves 95.1% structural accuracy on test data, surpassing the current state-of-t

SUBMITTER: Abtheen EA 

PROVIDER: S-EPMC12236585 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature