REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS.

ABSTRACT: Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing a human PF related mutation in the Surfactant Protein-C (SP-C) gene (SFTPC ^I73T ). Genetic crosses of SP-C^I73T mice with Foxp3^GFP and Foxp3^DTR lines were utilized to study Treg behavior during PF development. We found that FoxP3+Tregs accumulate during the transition from inflammation to fibrogenesis, peaking at 21-28 days after mutant Sftpc ^I73T induction localizing to both perivascular and distal fibrotic lung regions. Diphth

SUBMITTER: Murthy A 

PROVIDER: S-EPMC12236608 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature