Brainwide blood volume reflects opposing neural populations.

ABSTRACT: The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across levels of arousal. Studies supporting these views, however, measured neural activity as a bulk quantity, and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume associated with the same events across the mouse brain, and find that their relationship is consistent across brain regions but differs in two opposing brainwide neural populations. Functional Ultrasound Imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings in

SUBMITTER: Landemard A 

PROVIDER: S-EPMC12236663 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature