Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.

ABSTRACT: Mismatches between interacting mitochondrial and nuclear gene products in hybrids have been proposed to disproportionately contribute to the formation of early species boundaries. Under this model, genetic incompatibilities emerge when mitochondrial haplotypes are placed into a cellular context without their coevolved nuclear-encoded mitochondrial (n-mt) proteins. Although there is strong evidence that mitonuclear coevolution has contributed to reproductive isolation in some cases, it is less clear how far-reaching the effects of mitonuclear incompatibilities are in speciation. Does disrupting co-adapted mitonuclear genotypes have broad, genome-wide effects with numerous n-mt loci contributing to reproductive isolation? We leverage a system with several hybridizing species pairs (Xiphop

SUBMITTER: Kuster SA 

PROVIDER: S-EPMC12236695 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature