Pulsatile flow dynamics determine pulmonary arterial architecture.

ABSTRACT:

Background

Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries without the support of a pumping ventricle. In the context of this altered circulation (loss of cardiac-driven pulsatility), diverse pulmonary vascular complications develop, severely limiting survival. To date, the relationship between loss of arterial pulsatility and pulmonary vascular changes has not yet been investigated at the cellular level.

Methods

Using combined cardiac catheterization and cardiac MRI, we defined pulsatility loss in three dimensions (flow, pressure, and stretch) in the pulmonary arteries of SV-CHD patients in the Glenn stage. To assess the impact of pulsati

SUBMITTER: Spurgin S 

PROVIDER: S-EPMC12236705 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature