Phase-Specific Antibiotic Resistance Mechanisms in an <i>Escherichia coli</i> B Strain.

ABSTRACT: The majority of antibiotics developed to date target the fast-growing phase of bacteria, which typically occurs during active infection and resembles the exponential growth phase of laboratory-grown cultures. However, many pathogenic bacteria in the human body occupy environments where nutrients are limited and persist in a low-metabolic state, mirroring the stationary phase observed in laboratory-grown cultures. Bacteria in this latter phase are generally more resistant to antibiotics and are often responsible for recurrent infections. A comprehensive understanding of metabolic processes in both the exponential and stationary phases of bacterial growth could facilitate the development of phase-specific antibiotics. In this study, we adopted an untargeted proteomics approach to establish s

SUBMITTER: Terrazas-Lopez M 

PROVIDER: S-EPMC12236707 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature