The aryl hydrocarbon receptor interacting protein suppresses RNA virus-induced type I IFN and IL-6 in mouse macrophages.

ABSTRACT: Aryl hydrocarbon receptor (AhR) interacting protein (AIP) suppresses type I IFN production by interacting with and preventing the nuclear translocation of the transcription factor IRF7. The kinase TBK1 phosphorylates AIP to promote IRF7 binding and the inhibition of the type I interferon (IFN) response. However, it is unknown if AIP expression in innate immune cells is important to suppress type I IFN in the context of RNA virus infection in vitro and in vivo. In this study we generated myeloid cell-specific AIP conditional knockout mice (Aip ^fl/flxLysM-Cre) to investigate AIP regulation of innate immune signaling in myeloid cells. Bone marrow-derived macrophages (BMDMs) from Aip ^fl/flxLysM-Cre mice had diminished viral replication and incr

SUBMITTER: Kazzaz SA 

PROVIDER: S-EPMC12236720 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature