Metabolic control of enteroendocrine cell fate through a redox state sensor CtBP.

ABSTRACT: Enteroendocrine (EE) cells monitor the intestinal nutrient composition and consequently control organismal physiology through hormonal signaling. In addition to the immediate effects on hormone secretion, nutrients influence EE cell abundance by affecting the determination and maintenance of cell fate. EE cells are known to import and respond to dietary sugars, but how the sugar-induced changes in the intracellular metabolic state are sensed to control the immediate and long-term responses of EE cells, remains poorly understood. We report that the NADH binding transcriptional cofactor C-terminal binding protein (CtBP) acts at the interface between nutrient sensing and fate regulation of Drosophila larval EE cells, thus controlling organismal energy metabolism and survival on a high

SUBMITTER: Rovenko BM 

PROVIDER: S-EPMC12236740 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature