Influence of perinatal ampicillin exposure on maternal fecal microbial and metabolic profiles.

ABSTRACT: Indirect exposure to antibiotics during early life, via maternal intrapartum antibiotic prophylaxis (IAP) or postpartum maternal antibiotic usage, is increasingly common and has been epidemiologically linked to altered growth and immune developmental trajectories in offspring. Nevertheless, the underlying mechanisms remain poorly understood. Here, we explored the effects of antepartum and postpartum maternal ampicillin administration on the dams' fecal microbiome and metabolic profiles in vivo. Ampicillin caused a reproducible depletion of beneficial bacterial species belonging to the Muribaculaceae family, including Muribaculum intestinale and Duncaniella dubosii, and led to cohort-dependent enrichments of Enterococcus and Prevotella species. Thes

SUBMITTER: Zuffa S 

PROVIDER: S-EPMC12236745 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature