Pro-longevity compounds extend <i>Caenorhabditis elegans</i> male lifespan and reproductive healthspan.

ABSTRACT: Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the potential for sex-specific interventions remain understudied. To explore sex differences in the response to pro-longevity interventions, we utilized the C. elegans aging model and asked whether male lifespan and reproductive healthspan can be extended via compounds known to have pro-longevity effects in hermaphrodites. We tested seven different compounds at two concentrations each and found that lifespan was extended under all tested conditions. However, reproductive healthspan measured by mating success in late life improved under only two tested conditions, sulforaphane and metformin. Thes

SUBMITTER: Al-Saadi RS 

PROVIDER: S-EPMC12236753 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature