CD4⁺ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis.

ABSTRACT: Unresolved inflammation and fibrosis are the two key features of metabolic dysfunction-associated steatohepatitis (MASH), a progressive form of steatotic liver disease that can evolve into cirrhosis and liver cancer. Although innate immunity has been well studied in MASH, the role of CD4⁺ T cells remains underexplored despite their potential to coordinate immune responses by providing help to other immune cells, promoting inflammation, or regulating immune activity through effector and regulatory subsets. To better understand the role of CD4⁺ T cells in the pathogenesis of MASH, we comprehensively characterized hepatic CD4⁺ T cells in murine and human MASH at a single-cell protein, transcriptional, and functional level. Mass cytometry and CITE-sequencing re

SUBMITTER: Valenzuela-Perez L 

PROVIDER: S-EPMC12236817 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature