Measuring Regulatory Network Inheritance in Dividing Yeast Cells Using Ordinary Differential Equations.

ABSTRACT: Quantifying the inheritance of protein regulation during asymmetric cell division remains a challenge due to the complexity of these systems and the lack of a formal mathematical definition. We introduce ODEinherit, a new statistical framework leveraging ordinary differential equations (ODEs) to measure how much a mother cell's regulatory network is passed on to its daughters, addressing this gap. ODEinherit first estimates cell-specific regulatory networks through ODE systems, incorporating novel adjustments for non-oscillatory trajectories. Then, inheritance is quantified by evaluating how well a mother's regulatory network explains its daughter's trajectories. We demonstrate that precise quantification of this inheritance relies on pruning and adjustment for the network density. We benc

SUBMITTER: Wu W 

PROVIDER: S-EPMC12236845 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature