Mitochondrial Energy Transformation Capacity Influences Brain Activation During Sensory, Affective, and Cognitive Tasks.

ABSTRACT: Brain function relies on energy supplied by mitochondrial energy transformation, but how cellular energetics constrains neurological function and cognition remains poorly understood. Genetic defects in mitochondrial DNA cause rare mitochondrial diseases (MitoD) that offer a unique window to examine how mitochondria affects the brain and cognition, and the possibility to identify neural processes that are most energetically constrained. In this study, we assessed functional magnetic resonance imaging (fMRI) on 29 participants with MitoD and 62 matched controls during resting state and tasks probing cognitive (N-back task), affective (cold pain), and sensory (multisensory visual and auditory perception) functions. MitoD individuals exhibited significant cognitive deficits across a range of f

SUBMITTER: Bo K 

PROVIDER: S-EPMC12236849 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature