Gene-environment interactions contribute to blood pressure variation across global populations.

ABSTRACT: Understanding the interplay between genetic architecture and environmental exposures is essential for elucidating the biological basis of complex traits such as blood pressure (BP). Although gene-by-environment interactions (G×E) have been previously shown to contribute to BP variation, their role in multi-ancestry cohorts remains underexplored. We hypothesize that G×E effects may explain additional variance in BP traits across diverse populations, where environmental exposures and genetic backgrounds are more heterogeneous. Here, we present an evaluation of the importance of G×E on systolic (SP), diastolic (DP), and pulse pressure (PP) in a multi-ancestry subset of 25,000 individuals from the UK Biobank. We considered 23 lifestyle variables as the environmental exposures, and estimated va

SUBMITTER: Goda K 

PROVIDER: S-EPMC12236863 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature