Accelerated grey matter degeneration in relapsing remitting multiple sclerosis.

ABSTRACT:

Background

Grey matter (GM) atrophy has been suggested as the most accurate marker of neurodegeneration in multiple sclerosis (MS) progression. However, long-term comparisons between MS and healthy controls (HC) are rare, and the most significantly atrophying brain regions and their clinical importance still need robust and longitudinal validation.

Methods

This multi-cohort longitudinal observational study used two relapsing remitting MS (RRMS) cohorts (N=386, T₁w-scans=940) sampled for up to 12 years to map grey matter atrophy localisation and disease progression (Expanded Disability Status Scale (EDSS), Paced Auditory Serial Addition Test (PASAT), Fatigue Severity Scale (FSS)). The identified region-specific significant atrophy was compared with 2,163 HCs (T

SUBMITTER: Korbmacher M 

PROVIDER: S-EPMC12236879 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature