Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participants.

ABSTRACT: Brain-computer interfaces have enabled people with paralysis to control computer cursors, operate prosthetic limbs, and communicate through handwriting, speech, and typing. Most high-performance demonstrations have used silicon microelectrode "Utah" arrays to record brain activity at single neuron resolution. However, reports so far have typically been limited to one or two individuals, with no systematic assessment of the longevity, decoding accuracy, and day-to-day stability properties of chronically implanted Utah arrays. Here, we present a comprehensive evaluation of 20 years of neural data from the BrainGate and BrainGate2 pilot clinical trials. This dataset spans 2,319 recording sessions and 20 arrays from the first 14 participants in these trials. On average, arrays successfully rec

SUBMITTER: Hahn NV 

PROVIDER: S-EPMC12236888 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature