Conducting MRI trials in Alzheimer's patients: Challenges and Guidelines.

ABSTRACT: Combining pharmaceutical interventions with neuroimaging in Alzheimer's disease (AD) research presents logistical and methodological challenges. This perspective paper outlines early-phase experiences from a 7-tesla (7T) fMRI clinical trial involving individuals with mild cognitive impairment (MCI) and mild AD, highlighting recruitment hurdles and practical recommendations. From a pool of 1,000 patients, 475 had MCI or AD clinically diagnosed; following pre-selection and screening, only 6% met all inclusion criteria. Major barriers included exclusion due to comorbidities, difficulties with blood draws, miscommunication about study procedures, and unreported medical conditions discovered during MRI. Effective communication, often requiring caregiver involvement, was essential for obtaining

SUBMITTER: Dobrushina M 

PROVIDER: S-EPMC12236889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature