The cumulative prevalence of HIV-1 drug resistance in perinatal HIV.

ABSTRACT:

Objective

To describe acquired drug resistance mutations (DRMs) among children and adults with perinatal HIV stratified by age.

Design

A retrospective observational cohort study.

Methods

Data on demographics, antiretroviral therapy (ART), viral load, CD4 + cell count, and lifetime cumulative acquired DRMs was collected and disaggregated by birth era; pre and post 2000; 0-24 and at least 25 years ( n  = 113 vs. 167).

Results

Two hundred eighty individuals (median age 26 years, interquartile range 21-30), 235 (84%) Black ethnicity, 160 (57%) female, with median ART exposure 17 years. About 99.6% currently on ART, 205 (73%) integrase strand transfer inhibitor (INSTI) regimens, with 252 (90%) viral load less than 200 copies/ml. One hundred twenty-one of 280 (43%) a

SUBMITTER: Glenn JS 

PROVIDER: S-EPMC12237116 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature