Dolutegravir plus lamivudine downregulates cellular stress responses vs. three-drug HIV regimens.

ABSTRACT:

Objective

To compare the systemic and immune effects of two-drug regimens (2DR) and three-drug regimens (3DR) in people with HIV (PWH).

Design

In a cross-sectional study, multiomics data were analyzed in dolutegravir (DTG) plus lamivudine (3TC) 2DR and 3DR comprising DTG with two nucleoside reverse transcriptase inhibitors (NRTIs).

Methods

Data from the 2000HIV cohort of virally suppressed PWH on combination antiretroviral treatment (cART) regimens were analyzed. Groups included DTG + 3TC ( n  = 191), DTG + 3TC + abacavir (ABC) ( n  = 188), and DTG + tenofovir disoproxil fumarate or tenofovir alafenamide (TDF/TAF) + emtricitabine (FTC) ( n  = 115). Systemic functions were assessed via plasma protein profiling (Olink Explore, 2367 proteins), while peripheral blood mono

SUBMITTER: Rios-Vazquez V 

PROVIDER: S-EPMC12237123 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature