TTBK2 affects sperm quality by regulating the expression of centrosomal proteins and flagellar transporters during spermiogenesis in mice.

ABSTRACT: Sperm plays a crucial role in male reproduction, and only a certain number of normal progressive sperm can achieve oocyte fertilization. Revealing the regulatory mechanism of spermatogenesis will help to clarify the pathogenesis of male infertility. Tau tubulin kinase 2 (TTBK2) is a microtubule-associated protein and a serine/threonine protein kinase, which has been shown to participate in cilia formation. Although the formation of cilia and sperm flagella is similar, the specific role of TTBK2 in the formation of sperm flagella remains to be elucidated. In this study, Ttbk2 was found to be predominantly expressed in the mouse testis, and the protein co-localized with α-tubulin in manchette during spermatogenesis. We inhibited the expression of Ttbk2 by intratesticular injection and found

SUBMITTER: Chang T 

PROVIDER: S-EPMC12237516 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature