Dietary acid load on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial.

ABSTRACT:

Background

Evidence suggests that changes in dietary acid load may influence body weight, and the purpose of this secondary analysis was to assess its role in the context of the Mediterranean and a vegan diet in overweight adults.

Methods

In this randomized cross-over trial, 62 overweight adults were randomized to a Mediterranean or a low-fat vegan diet for 16-weeks, separated by a 4-week washout. Change in body weight was the primary outcome. Three-day dietary records were analyzed, and Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) were calculated as markers of dietary acid load, and their relationship was tested with changes in body weight.

Results

Compared with no change on the Mediterranean diet, PRAL and NEAP significantly decreased o

SUBMITTER: Kahleova H 

PROVIDER: S-EPMC12237638 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature