Inhibitory Learning-based Exposure Response Prevention Therapy in Obsessive-compulsive Disorder: A Development and Efficacy Trial Protocol.

ABSTRACT:

Background

Serotonin reuptake inhibitors (SSRIS) and cognitive behavior therapy (CBT), comprising exposure and response prevention (ERP), are the first line of treatment for obsessive compulsive disorders (OCD). However, many patients fail to achieve clinically significant symptom relief from traditional exposure-based therapies. This has led to research on strategies that can optimize the effects of ERP. Inhibitory learning theory (ILT) provides a novel foundation for understanding how exposure therapy reduces fear and has been mainly studied in the context of anxiety and phobia.

Novelty

There is limited empirical data on applying the principles of IL, such as expectancy violation, variability, deepened extinction, labelling of affect, and removal of safety signals as mecha

SUBMITTER: Thampy M 

PROVIDER: S-EPMC12237942 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature