Dual blockage of P-cadherin and c-Met synergistically inhibits the growth of head and neck cancer.

ABSTRACT:

Purpose

P-cadherin (CDH3) is a transmembrane protein that plays a crucial role in maintaining the structural integrity of epithelial tissue and homeostasis. Its role in carcinogenesis remains a subject of debate, as its behavior can vary depending on the molecular context and the specific tumor cell model under study. In this study, we explored the role of P-cadherin in head and neck squamous cell carcinoma (HNSCC) and the mechanisms underlying its function.

Methods

We analyzed P-cadherin expression in HNSCC patients using The Cancer Genome Atlas (TCGA), The Chungnam National University Hospital (CNUH) cohort and Gene Expression Omnibus (GEO) database. For in vitro functional analysis, we conducted proliferation, migration, invasion, and western blot assays after either supp

SUBMITTER: Liu L 

PROVIDER: S-EPMC12238114 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature