CCL22 as a diagnostic and prognostic biomarker for pediatric-onset systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by diverse symptoms and multisystem involvement. Pediatric-onset systemic lupus erythematosus (pSLE) accounts for 10-20% of all SLE cases and tends to progress more rapidly and severely than adult-onset SLE, making diagnosis more challenging. Current biomarkers remain insufficient in predicting disease severity and organ-specific complications, highlighting the need for new biomarkers.

Methods

This study included 36 pSLE patients and 18 age and gender matched healthy controls. Serum CCL22 levels were measured by luminex immunoassay. Correlations between CCL22, disease activity (SLEDAI), and 40 laboratory indicators were analyzed using Pearson correlation. Receiver operating characteristic cu

SUBMITTER: Chen XL 

PROVIDER: S-EPMC12238133 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature