Expression profile and prognostic relevance of immune infiltration-related RBMS1 in gliomas: a multidimensional integrative analysis.

ABSTRACT:

Purpose

This study investigates the expression characteristics of RNA binding motif single stranded interacting protein 1 (RBMS1) in gliomas and its associations with clinicopathological features, immune infiltration, and prognosis, aiming to evaluate its potential as a prognostic biomarker.

Methods

Differentially expressed genes (DEGs) were screened from the GEO datasets GSE43378 and GSE178621 (thresholds: P < 0.05,|logFC|> 1), with RBMS1 validated via the TCGA and GEPIA databases. Correlations between RBMS1 and immune infiltration were assessed using the TISIDB. Correlations between RBMS1 and immune checkpoint molecules, costimulatory genes, and chemokines were also explored using GEPIA. Immunohistochemistry (IHC) was performed on 165 glioma and 62 normal brain tissues to

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12238165 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature