Different neutrophil extracellular trap related Ewing sarcoma subtypes exhibit distinct prognosis, and immune microenvironment characteristics.

ABSTRACT: Ewing sarcoma (EWS) is a rare bone cancer that is most usually detected in children. Neutrophil extracellular traps (NETs) are closely related to the prognosis of cancer, but the significance of NET-related features in EWS remains uncertain. We constructed a NET signature utilizing four crucial NET-related genes in EWS to forecast prognosis and investigate the potential immunological value of this signature in EWS. EWS data were collected from the International Cancer Genome Consortium and Gene Expression Omnibus databases. We identified the subtypes mediated by NET-related genes in EWS and analyzed the function infiltration and immune signature of NET-related subtypes in EWS. The expression levels of proteins in EWS cells were detected via western blotting analysis. NET could distinguish

SUBMITTER: Li S 

PROVIDER: S-EPMC12238249 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature