Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis.

ABSTRACT:

Introduction

The prognostic value of subcortical gray matter structures for dementia beyond the hippocampus remains unclear.

Methods

We included participants with subjective cognitive decline or mild cognitive impairment from two memory clinic-based cohorts (Amsterdam Dementia Cohort and National Alzheimer's Coordinating Center) and one population-based cohort (Rotterdam Study). We assessed volumes of subcortical structures on magnetic resonance imaging and determined 5-year dementia risk using Cox models.

Results

Of 7076 participants (mean age: 66-69 years, 58.8%-61.0% women; N_SCC = 5425, N_MCI = 1661), 622 developed dementia within 5 years. Smaller volumes of the hippocampus and amygdala were consistently associated with increased dementia risk,

SUBMITTER: Rosbergen MT 

PROVIDER: S-EPMC12238309 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature