Magnetic iron-oxide nanoparticles in the brain connected to alcohol-associated liver disease.

ABSTRACT: Magnetic iron-oxide nanoparticles in the form of magnetite (Fe₃O₄) are present in the human brain. They have been hypothesized to biomineralize in situ, as a result of dysfunctional iron homeostasis related to Alzheimer's disease, or to enter the brain as airborne pollution particles. Regardless of their origin, magnetic iron-oxides pose a potential hazard to human health due to their high redox activity and surface charge. Here we report measurements on four post-mortem human brainstems, with one brainstem showing approximately 100 times higher magnetite concentrations than the other cases. This brainstem came from a subject with alcohol-associated liver disease (ALD) that manifested in liver cirrhosis and massive hepatic iron overload. Laser ablation - inductively c

SUBMITTER: Kaub L 

PROVIDER: S-EPMC12238357 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature