Novel approach in treatment of <i>Burkholderia pseudomallei</i> osteomyelitis: salvage therapy with levonadifloxacin.

ABSTRACT:

Background

Melioidosis, caused by Burkholderia pseudomallei, is a deadly infection with a case fatality rate of 10%-50%. Osteomyelitis, a rare manifestation, is particularly challenging due to diagnostic delays, misidentification, limited bone penetration of antibiotics and frequent relapses. Antibiotic intolerance emerges as a significant hurdle, with up to 26%-51% of patients developing severe allergies to trimethoprim/sulfamethoxazole, along with intolerability to ceftazidime and meropenem. These limitations demand innovative therapeutic approaches to combat this pathogen.

Objectives

To report a novel case of B. pseudomallei-induced radial osteomyelitis successfully managed with levonadifloxacin, a broad-spectrum benzoquinolizine antibiotic, after intoleranc

SUBMITTER: Gupta N 

PROVIDER: S-EPMC12238538 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature