Exploring the role of two polypeptide nanofiber gels derived from RADA16-I self-assembly in accelerating burn wound healing.

ABSTRACT: This study systematically evaluates the therapeutic effects and molecular mechanisms of peptide nanofiber gels RG and RJ in deep second-degree burn wound healing. The gels are composed of the self-assembling peptide RADA16-I (R) conjugated with either a GLP-1 analog (G) or Jagged-1 protein (J), both of which exhibit good physicochemical properties, including well-defined three-dimensional nanofiber architectures, transparent gel consistency, and significantly enhanced mechanical strengths (storage modulus increased by ~ 4.3-fold for RG and ~ 7.09-fold for RJ) with high composite viscosities (5.36 Pa·s for RG; 7.08 Pa·s for RJ). In vitro experiments demonstrated that RG and RJ significantly promoted cell proliferation and migration. In vivo studies revealed that RG and RJ accelerated the he

SUBMITTER: Song C 

PROVIDER: S-EPMC12238610 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature